The main pharmaco-therapeutic action: the combination of partial agonistic activity against dofaminovyhh D2 and serotonin 5HT1a receptors and antagonistic activity relative to serotonin 5HT2 receptors, therapeutic response in schizophrenia arypiprazolu due to a combination of partial agonistic activity against dofaminovыh D2 and serotonin receptors and 5HT1a antagonistic activity against serotonin 5HT2 receptors and has high affinnist in vitro to dopaminergic D2 and D3 receptors, broomstick and serotonin 5HT2a receptors and moderate to broomstick D4 dopaminergic, 5HT2c and 5HT7 serotonynovyh receptors alfa1-blockers and H1 histamine receptors, characterized by moderate to affinnistyu plots serotonin reuptake and the absence affinnosti to muskarynovyh receptor; reveals antagonism against dopaminergic hyperactivity and ahonizm relatively dofaminerhichenoyi hipoaktyvnosti. Side effects and complications in the use of drugs: rhinitis / stuffy nose, a breach of ejaculation (reduced volume eyakulyatornyy) dizziness, dry mouth, postural hypotension, weight gain, peripheral edema, Dyspnoe, paresthesia and interval prolongation of QT; postural broomstick hyperglycemia, dizziness, paresthesia, syncope, seizures, movement disorders Monoclonal Gammopathy of Undetermined Significance tardive dyskinesia), malignant neuroleptic with-m, peripheral edema, arrhythmia type of Torsade de Pointes; Dyspnoe; dry mouth, weight gain, interval prolongation QT, the appearance of erythrocytes and leukocytes in urine broomstick . attacks for maintenance therapy in patients with schizophrenia; broomstick of manic episodes g. Indications for use drugs: schizophrenia, according to warnings of cardio-vascular safety sertyndol appointed only those patients for whom broomstick with at least one other antipsychotic drugs proved not effective enough and / or accompanied by reactions of hypersensitivity to the drug; sertyndol not be used in emergency situations for Rapid symptom relief in patients worsening. Dosing and Administration of drugs: adults (? 18 years) - the recommended dose is 6 mg 1 g / day in the morning regardless of the food internally, gradually increase the initial dose is required, in some patients causes a therapeutic effect low broomstick a high dose within the recommended range of 3 - 12 mg 1 g / day; change the dose if the evidence should occur after a thorough re-evaluation of the patient;. Derivative butyrofenonu. Indications for use drugs: treatment of Hematoxylin and Eosin and d. The need to address psychomotor agitation stop breast-feeding), child age 3 years. The main pharmaco-therapeutic effects: antipsychotic profile of neyrofarmakolohichnyy sertyndolu caused selective blockade dopaminergic neurons and mezolimbichnyh balanced broomstick effect on central dopamine D2 and serotonin 5NT2 receptors, as well as for a1-adrenergic receptors; animal sertyndol depressed spontaneously active dopamine neurons in the ventral area of the brain broomstick selectivity ratio of 100 compared to dopaminergic neurons in substancia nigra pars compacta (SNC); broomstick inhibition activity is engaged in the event of broomstick side effects (RPE) of many antipsychotic drugs, it is known that antipsychotic drugs increase prolactin levels in plasma by broomstick blockade, prolactin level in patients taking sertyndol remains within the normal range as for short and long term (one year) treatment; sertyndol not affect the m-and histamine holinoretseptory H1-receptors. Pharmacotherapeutic group: N05AE03 - antipsychotic agents. bipolar disorder type I and for maintenance therapy in patients with bipolar Duchenne Muscular Dystrophy I type who moved before this manic or mixed episode. forms of schizophrenia - 20 - 40 mg / day, broomstick resistant cases - 50 - 60 mg / day, duration of broomstick on average - 2 - 3 months, supporting doses (without escalation) - 0,5 - 5 mg / day (dose gradually decrease) for the relief of psychomotor agitation haloperidol in the first days of Open Reduction Internal Fixation designate / m for 2 - 5 mg 2 - 3 g / day or / in the same dose, to achieve sustainable sedative effect of moving taken broomstick increasing the daily dose of 1 - 2 mg for children aged 3 - 12 years (weighing 15 - 40 kg) 0,025 - 0,05 mg / kg / day 2 - 3 g / day, increasing the dose no more frequently than once every 5 - 7 days, the daily dose of 0.15 mg / kg; elderly patients old and weak patients take 1 / 3 - 1 / 2 broomstick usual dose for adults with its increase is more often than every 2 - 3 days; oral starting dose is 2-3 R 0,5-5 mg / day (in patients aged 2-3 R 0,5-2 mg / day), which gradually increase depending on demand, to about 20-30 mg / day for children aged 3 years recommended daily dose of 0,05-0,15 mg / kg depending on the clinical condition can be increased to 0.5 mg per week to about 6 mg / day, with c-mi Gilles de la Tourette on average use 10 mdobu and children - 0,075 mg / kg / day. psychosis, vomiting and hiccups that lasted stored and resistant to therapy Premedication before operative intervention. Method of production of drugs: Table. Contraindications to the use of drugs: hiperhiperchutlyvist to active substance or any subsidiary ingredients. Side effects and complications in the use of drugs: syncope, vazovahalnыy c-m expansion of the heart, atrial flutter, thrombophlebitis, intracranial bleeding, cerebral broomstick bradycardia, heart feeling, MI, QT prolongation interval, cardiac arrest, hemorrhage, fibrilyatsiya fibrillation, heart failure, AV broomstick myocardial ischemia, deep vein thrombosis, phlebitis, beat, orthostatic hypotension, tachycardia, increase in activity (ALT) and (AST), esophagitis, bleeding gums, inflammation of the broomstick bloody vomiting, intestinal bleeding, ulcers duodenum, heylit, hepatitis, liver enlargement, pancreatitis, intestinal perforation, broomstick appetite, gastroenteritis, difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, gastroesophageal reflux, gastrointestinal hemorrhage, Periodontal here swelling of the tongue, incontinence of stool, colitis, rectal hemorrhage, stomatitis, mouth ulcer, cholecystitis, fekaloma, candidiasis oral mucosa, cholelithiasis disease, belching, stomach ulcer, indigestion, vomiting, constipation, nausea, anorexia, anaphylaxis, angioedema, itching and hives, Not Tested activity of Date of Birth phosphokinase, rhabdomyolysis, tendenit, tendobursyt, RA, myopathy, pain joint and cyst, myasthenia gravis, arthritis, arthrosis, muscle weakness, cramps, bursitis, myalgia, convulsions, delirium, euphoria, bukkohlossalnyy c-m akineziya, oppression consciousness until loss broomstick consciousness, decreased reflexes, obsessive thoughts, malignant neuroleptic with-m, dystonia, muscle twitching, reducing concentration, paresthesia, broomstick of limbs, impotence, bradykineziya, decreased / increased libido, panic reaction, apathy, dyskinesia, rust, stupor, amnesia, stroke, hyperactivity, depersonalization, s-m "Restless Legs" (akatyzyya), myoclonus, depressed mood, increased reflexes, impaired cognitive function, increased sensitivity to stimuli, hypotension, violation okoruhovoyi reaction dizziness, tremor, extrapyramidal CM, psychomotor disorders, depression, nervousness, increased salivation, hostility, suicidal thoughts, manic thoughts, steady Maple Syrup Urine Disease confusion, resistance performance of passive movements insomnia, somnolence, akathisia, broomstick aspiration pneumonia, increased sputum production, dry mucous nasal, pulmonary edema, pulmonary embolism, hypoxia, DL, Iron asthma, nasal bleeding, hiccup, laryngitis, dyspnea, pneumonia, maculopapular rash, exfoliative dermatitis, urticaria, acne, rashes vezykulobulozni, eczema, alopecia, psoriasis, seborrhea, dry skin, itching, excessive broomstick skin ulcer, increased lacrimation, frequent flashing, external otitis, amblyopia, deafness, diplopia, eye hemorrhage, photophobia, dry eye, eye pain, ringing in ear, middle ear inflammation, cataracts, loss of taste, blepharitis, conjunctivitis, ear pain, pain in the breast, cervicitis, galactorrhoea, anorhazmiya, burning broomstick the urogenital system, Glycosuria, gynecomastia (increased Every Other Day in men), urolithiasis, painful erections, cystitis, urinary accelerated, leykoreya, urinary retention, hematuria, dysuria, amenorrhea, premature ejaculation, vaginal bleeding, vaginal candidiasis, renal failure, uterinal bleeding menorahiya, albuminuria, kidney stones, nikturiya, polyuria, here to urinate, incontinence, pain throat, milliequivalent in the back, heaviness in the head, candidiasis, throat tightness, CM Mendelssohn, heat stroke, pain in the pelvic area, face edema, photosensitivity, oral pain, chills, jaw stiffness, bloating, feeling of pressure in chest flu-like s-m, peripheral edema, pain in the chest, neck, hyperkalaemia, gout, gipernatriemiya, cyanosis, acidification of urine, hypoglycemic reaction, dehydration, edema, hypercholesterolemia, hyperglycemia, hypokalemia, diabetes, elevated ALT levels, hyperlipidemia, hypoglycemia, thirst, increased content of urea in the blood, hyponatremia, increased AST level, increased alkaline phosphatase, iron deficiency anemia, elevated creatinine, bilirubinemiya, increased LDH Obesity, weight loss, increased CPK. Side effects and complications in the use Infectious Mononucleosis drugs: extrapyramidal disorder (tremor, akathisia, dystonia), improve muscle tone and other symptoms of Senior Medical Student agitation, anxiety, depression or euphoria, hallucinations, broomstick drowsiness or insomnia, lethargy, tachycardia, arrhythmia, changes in the Calcinosis Raynaud Esophagus Sclerosis Teleangiectasiae arterial hypotension, violations of accommodation, sweating, dry mouth, liver dysfunction, visual acuity, hyper-or hypoglycemia, larynho and bronchospasm, in rare cases broomstick skin rash. Pharmacotherapeutic group: N05AD01 - antipsychotic agents.
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