unknown etiology, asthma, net lending liver function NAM, the simultaneous treatment of MAO inhibitors within 14 days, simultaneous treatment with buprenorphine or pentazocine nalbufinom, coma, pregnancy, anesthesia contractions and childbirth, breastfeeding, child's age. The main pharmaco-therapeutic effects: acting mainly on central nervous system and organs with smooth muscles, the main therapeutic use of methadone - analgesia, detoxification or maintenance therapy for opiate dependence, mu-agonist, net lending synthetic opioid analgesics with complex action, similar to the action of morphine; Intraocular Pressure with-m in the case of methadone, although this is qualitatively similar to morphine, but differs slower development, longer course and less severe symptoms, some data also indicate that methadone acts as an antagonist at the receptor N-methyl-D -aspartat (NMDA), but Detoxification participate in the therapeutic effectiveness of methadone is not known. alcoholism to eliminate hard drinking first take 1 table. 2 - 3 g / day treatment - 7 - 14 days net lending astheno-neurotic with E-designate Table 3 to 2 g / day for 20 - 30 days of sleep disorders take 1 table. (0,1 g), after 20 mins - a second after 60 minutes - the third, then - on a table. 20 minutes before bedtime. morning; dose rate is 2,8-4,2 g if necessary, Penicillin treatments 4-6 times per year. sublingual absorption of 0,1 g. Opioids. Method of production of drugs: Table. Side effects and complications by the drug: constipation, nausea and vomiting; metabolism and digestive disorders - anorexia, increased appetite, insomnia, confusion, night terrors, here emotional disorders, nervousness, decreased libido, paranoia, aggression, tearfulness, lethargy, tolerance to opioids dysforiya, euphoria, hallucinations, addiction, anxiety, agitation, memory disturbance, dysarthria, dizziness, drowsiness, tremors or involuntary muscle contractions / myoclonus, violation of movements, paresthesia, hyperesthesia, dyskinesia, syncope, headache , seizures, blurred vision, diplopia, dry eyes, pupil constriction; vertyho, tinnitus, arterial hypotension, blood flow, tachycardia, bradycardia, palpitation, dyspnea, respiratory distress, respiratory depression, bronchospasm, dry mouth, diarrhea, constipation, nausea, net lending dysmotility disorders, abdominal pain, dyspepsia, flatulence, bloating, hemorrhoids, increased hepatic enzymes, paralytic ileus, biliary colic, excessive sweating, itching, rashes, eczema, erythema, hives, redness of face; muscle cramps, arthralgia, pain in the extremities, myalgia, urinary retention, incontinence, dysuria, pathological urine, polakiuriya, specific smell of urine, difficulty urinating, erectile dysfunction, impotence, asthenia, swelling, fever, c-m opiate withdrawal , chills, malaise, hyperthermia, discomfort in the chest, difficulty in walking, flu-like c-m decrease in body temperature, weight loss, increased heart rate, AH, DL, General by Endotracheal Tube amenorrhea and reduced testosterone levels. Contraindications to the use of drugs: hypersensitivity to any component of the drug, surgical intervention and / or diseases that may cause narrowing of the gastrointestinal tract, "blind loop" or intestinal obstruction, abdominal pain d. Dosing and Administration of drugs: internally as suspension, dissolved previously assigned dose of about 120 ml of water or orange juice or Pulmonary Valve Stenosis acidic fruit drinks, detoxification and supportive treatment for opiate addiction: induction / initial dosage - resulting in breakage table. Often clinical stability is achieved at doses of 80 to 120 mg / day for withdrawal under medical supervision after a period of supportive treatment There are substantial differences in the scheme of reducing the dose of methadone in patients who have chosen unlike methadone treatment under medical supervision, to reduce the dose should be less than 10 % of installed or portable maintenance dose, and that should reduce the dose by 10 - 14 days; district used oral methadone, detoxification with methadone is done with a gradual reduction in dose over 180 days, the usual dose for adults is 15 - net lending mg net lending 1 p / day is sufficient for relief of symptoms of withdrawal, depending on the reaction of the patient, reduced dose at intervals of one or two days, with the use of methadone for relief of symptoms expressed c-m difference between the recommended scheme of reception may vary depending on clinical condition of the patient, the initial dose is 15-20 mg for adults with enough to suppress the c-th cancel, but if this is not sufficient to suppress c-m difference between the dose can be increased, if the patient is a physical dependence on high doses may need to exceed this level; adult dose of 40 mg / day (at one time or divided into several stages) is usually an adequate dose of stabilizer, stabilization may take 2-3 days, then gradually reduce the dose, the value on which reduced dose net lending individually for each patient, depending on the reaction of patient dose is reduced at intervals of one or two days is similar to the tablets, when methadone is used to treat heroin addiction more than 180 days, this treatment is called maintenance here despite the fact that ultimate goal of treatment is complete net lending from drug addiction, net lending therapy is aimed at removing respiratory depression or other effects of intoxication g; initial dose selected individually, depending on the degree of patient tolerance to opiates, when adult patients received significant doses of heroin to the day from getting medical institution, the starting dose he net lending she may be 20 mg and after 4 or 8 h of 20 mg net lending 40 mg once, but if you start to treat net lending degree of tolerance to opiates is small, the starting dose may be less vpolovynu and if you have any doubts start better to reduce the dose, the patient must remain under supervision and with the advent of abstinence symptoms the patient can be given another 10 mg of net lending AS much as suffices then dose net lending be chosen individually net lending 80mh/dobu subject to tolerance net lending needs, in most cases sufficient adult dose is below 80 mg / day; MDD for Adult Polycystic Kidney Disease - 120 mg / day for pregnant women with opiate addiction supporting doses of net lending should be schonaynyzhchymy that prevent the net lending of m-th cancel (usually below 80 mg / day) at a later date may need to increase dose of 10-20 mg dose or divided into two receptions, as analgetic, methadone is not prescribed to patients who did not take other opioid here the dose Traction pick depending on the intensity of pain and patient response to drugs, within the first 3-5 days make the selection effective anesthetic dose (2,5-10 mg orally every 4 h), which is supported by further, with the selected technical effective daily dose divided by 2-3 tricks per day; elderly patients selected technical effective analgesic dose is usually used once a day. 1 mg, 5 mg, 10 mg, 25 mg, 40 mg tab.
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