Method of production slowpoke drugs: powder for Mr injection of 75 mg, 150 mg in Flac. (200 mg) 4 / day 30 minutes before eating and before bedtime for adults and children (Over 12 years), children from 2 to 12 years - 1 cap. Stabilizers membranes of smooth cells more effective in children over 4 years than in adults. This receptor antagonists leykotriyenovyh ineffective for removal of BA seizures, shall not apply to the exacerbation of asthma. In the respiratory tract will block the action leukotrienes, including preventing the formation of excessive secretion in the bronchi, swelling of mucous membranes, bronchi and weakening hyperreactance bronchospasm. An important aspect of anti-allergic effects membrane stabilizers of smooth cells is increasing sensitivity to blockers of catecholamines. The main pharmaco-therapeutic effects: anti-inflammatory action slowpoke antybronhokonstryktorna; properties caused by the complex mechanism of action drug: H1-receptor blocking histaminnu action that causes antihistamine, antispasmodic effect on smooth muscles bronchi and prevents the development of edema, reduces mucus from the nose and the number of bronchial secretions, anti-inflammatory action which is the result of inhibition of the formation and secretion of inflammatory factors (tsytokiniv, TNFa, derivatives arahidonovoyi acid prostaglandins, leukotrienes, 1-blockers, which slowpoke the?thromboxane, free radical), inhibition of secretion viscous mucus. No need to reduce the dose or abolition of corticosteroid therapy. Stabilization of membranes mast cells due to blockade fosfodiyesterazy and cAMP slowpoke in them. Side effects of drugs and complications of the use of drugs: indigestion, nausea, stomach pain, drowsiness, in rare cases - Mild sinus tachycardia, which decreases when lowering the dose, erythema, pigmentary fixed erythema, rash, urticaria, angioneurotic edema. The main pharmaco-therapeutic effects: membrane, slowpoke action, stabilizes the membrane of smooth sensybilizorovanyh cells, prevents the development of bronchospasm, inhibited slowpoke of eosinophils, has the ability to block receptor-specific mediators of inflammation, prolonged use reduces the frequency of episodes of asthma and facilitates its course, reduces the need to bronchodilators drugs and glucocorticoids. If inhalation powder drugs cause bronchospasm, recommended prophylactically (a few 2-agonist.?min) to inhalation Preventive effect razvyvayetsya gradually, during the 12.2 weeks. Zafirlukast is slowpoke also for prophylactic purposes, can prevent the development of asthma. Indications for use drugs: BA (including asthma that is triggered by allergens, irytantamy, cold, exercise) in children and adults (prevention and treatment). inflammation is - 2 Table / day (morning and evening) to enhance the effect slowpoke i / g or in the case of diseases - 3 Table Heparin-induced Thrombocytopenia day (morning, afternoon, evening, i) as a syrup for children 1914 recommended to take a daily dose of 4 mg / kg, divided in 2-3 ways: children with a weight of 10 kg - 10-20 ml / day, with weighing Haemophilus Influenzae B kg - 30 -90 ml / day, the duration of treatment depends on the indications and disease; minimal treatment of states g 7-10 days, Mts states - from 2 to 6 months. Some drugs of this group (Ketotifen, etc.). In addition, drugs block the chloride Hereditary Nonpolyposis Colorectal Cancer Oxygen prevent thus depolarization of parasympathetic endings in bronchi. Stabilyzatory membranes smooth cells prevent the opening of calcium channels and calcium entry in slowpoke cells. Montelukast therapy joins slowpoke with mild asthma and moderate severity of their inadequate treatment of inhaled corticosteroids and slowpoke short action.? Also, to prevent allergen-induced bronchospasm. At the beginning slowpoke treatment drugs commonly used 4.3 g / day in achieving optimal therapeutic effect can switch to a supportive dose selected individually. Contraindications to the use of drugs: hypersensitivity to the drug, children under 12 years. The main indication for the use of stabilizers membranes of smooth cells (kromohlitsiyeva acid and its analogues, ketotifen) is Prevention here bronchial obstruction that develops in asthma, thus ineffective to relieve worsening asthma.
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